Grace Martindale has known more than her share of hardship. After her parents died, raising her two younger sisters became her responsibility. A hasty marriage to a minister who is heading to the untamed West seemed like an opportunity for a fresh start, but a cholera outbreak along the wagon trail has left Grace a widow in a very precarious position. Having learned natural remedies and midwifery from her mother, Grace seeks an opportunity to use her skills for the benefit of others. So when she and her sisters arrive at the Whitman mission in "Oregon Country," she decides to stay rather than push on. With the help of Alex Armistead, a French-American fur trapper, Grace begins to provide care for her neighbors, including some of the native populace. But not everyone welcomes her skills--or her presence--and soon Grace finds herself and those she loves in more danger than she imagined possible.